Arc Institute's Bolero predicts how each cell reads the same DNA
Every cell in your body carries the same DNA, yet cells read it very differently. In a new preprint, Arc Institute Science Fellow @zhou_jingtian and team introduce Bolero, a model conditioned on cell state that, according to Arc, predicts chromatin accessibility and gene expression from DNA sequence alone. Tools like this could help researchers understand how genetic variants affect specific cell types. These details come from the post by @arcinstitute.